Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune ada...
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Cyclic GMP-AMP containing a unique combination of mixed phosphodiester linkages (2â²3â²-cGAMP) is an endogenous second messenger molecule that activates the type-I IFN pathway upon binding to the homodimer of the adaptor protein STING on the surface of endoplasmic reticulum membrane. However, the preferential binding of the asymmetric ligand 2â²...
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Full title
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
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TN_cdi_pubmed_primary_26150511
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26150511
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1507317112
