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Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
Author / Creator:Eaglesham, James B. ; Pan, Youdong ; Kupper, Thomas S. ; Kranzusch, Philip J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-02, Vol.566 (7743), p.259-263
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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Author / Creator:Chen, Qing ; Boire, Adrienne ; Jin, Xin ; Valiente, Manuel ; Er, Ekrem Emrah ; Lopez-Soto, Alejandro ; S. Jacob, Leni ; Patwa, Ruzeen ; Shah, Hardik ; Xu, Ke ; Cross, Justin R. ; Massagué, Joan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-05, Vol.533 (7604), p.493-498
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The structural basis for 2′−5′/3′−5′-cGAMP synthesis by cGAS
Author / Creator:Wu, Shuai ; Gabelli, Sandra B. ; Sohn, Jungsan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.4012-4012, Article 4012
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cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila
Author / Creator:Slavik, Kailey M. ; Morehouse, Benjamin R. ; Ragucci, Adelyn E. ; Zhou, Wen ; Ai, Xianlong ; Chen, Yuqiang ; Li, Lihua ; Wei, Ziming ; Bähre, Heike ; König, Martin ; Seifert, Roland ; Lee, Amy S. Y. ; Cai, Hua ; Imler, Jean-Luc ; Kranzusch, Philip J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-09, Vol.597 (7874), p.109-113
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Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
Author / Creator:Li, Tiejun ; Cheng, Hao ; Yuan, Hong ; Xu, Qiming ; Shu, Chang ; Zhang, Yuefan ; Xu, Pengbiao ; Tan, Jason ; Rui, Yaocheng ; Li, Pingwei ; Tan, Xiangshi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-01, Vol.6 (1), p.19049, Article 19049
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Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger
Author / Creator:Fatma, Shirin ; Chakravarti, Arpita ; Zeng, Xuankun ; Huang, Raven H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-11, Vol.12 (1), p.6381-6381, Article 6381
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cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans
Author / Creator:Patel, Dinshaw J. ; Yu, You ; Xie, Wei
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2023-03, Vol.30 (3), p.245-260
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Viruses transfer the antiviral second messenger cGAMP between cells
Author / Creator:Bridgeman, A. ; Maelfait, J. ; Davenne, T. ; Partridge, T. ; Peng, Y. ; Mayer, A. ; Dong, T. ; Kaever, V. ; Borrow, P. ; Rehwinkel, J.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-09, Vol.349 (6253), p.1228-1232
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Hybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3′, 3′-cGAMP)
Author / Creator:Hallberg, Zachary F. ; Wang, Xin C. ; Wright, Todd A. ; Nan, Beiyan ; Ad, Omer ; Yeo, Jongchan ; Hammond, Ming C.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1790-1795
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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Author / Creator:Li, Xiao-Dong ; Wu, Jiaxi ; Gao, Daxing ; Wang, Hua ; Sun, Lijun ; Chen, Zhijian J.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-09, Vol.341 (6152), p.1390-1394
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Homogeneous and bioluminescent biochemical and cellular assay for monitoring cGAMP and enzymes that generate and degrade cGAMP
Author / Creator:Hsiao, Kevin ; Murray, Nathan H. ; Mikheil, Dareen ; Larsen, Matthew A. ; Wang, Hui ; Ugo, Tim ; Goueli, Said A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-12, Vol.14 (1), p.31165-11, Article 31165
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Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict
Author / Creator:Eaglesham, James B ; McCarty, Kacie L ; Kranzusch, Philip J
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-11, Vol.9 (2020)
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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
Author / Creator:Jønsson, K. L. ; Laustsen, A. ; Krapp, C. ; Skipper, K. A. ; Thavachelvam, K. ; Hotter, D. ; Egedal, J. H. ; Kjolby, M. ; Mohammadi, P. ; Prabakaran, T. ; Sørensen, L. K. ; Sun, C. ; Jensen, S. B. ; Holm, C. K. ; Lebbink, R. J. ; Johannsen, M. ; Nyegaard, M. ; Mikkelsen, J. G. ; Kirchhoff, F. ; Paludan, S. R. ; Jakobsen, M. R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-02, Vol.8 (1), p.14391-14391, Article 14391
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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Author / Creator:Ablasser, Andrea ; Schmid-Burgk, Jonathan L. ; Hemmerling, Inga ; Horvath, Gabor L. ; Schmidt, Tobias ; Latz, Eicke ; Hornung, Veit
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-11, Vol.503 (7477), p.530-534
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Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Author / Creator:Li, Lingyin ; Yin, Qian ; Kuss, Pia ; Maliga, Zoltan ; Millán, José L ; Wu, Hao ; Mitchison, Timothy J
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2014-12, Vol.10 (12), p.1043-1048
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Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Author / Creator:Li, Lingyin ; Yin, Qian ; Kuss, Pia ; Maliga, Zoltan ; Millán, José L ; Wu, Hao ; Mitchison, Timothy J
Publisher:United States: Nature Publishing Group
Journal title:Nature chemical biology, 2014-12, Vol.10 (12), p.1043-1048
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Transmission of innate immune signaling by packaging of cGAMP in viral particles
Author / Creator:Gentili, Matteo ; Kowal, Joanna ; Tkach, Mercedes ; Satoh, Takeshi ; Lahaye, Xavier ; Conrad, Cécile ; Boyron, Marilyn ; Lombard, Bérangère ; Durand, Sylvère ; Kroemer, Guido ; Loew, Damarys ; Dalod, Marc ; Théry, Clotilde ; Manel, Nicolas
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-09, Vol.349 (6253), p.1232-1236
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Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
Author / Creator:Kato, Kazuki ; Nishimasu, Hiroshi ; Oikawa, Daisuke ; Hirano, Seiichi ; Hirano, Hisato ; Kasuya, Go ; Ishitani, Ryuichiro ; Tokunaga, Fuminori ; Nureki, Osamu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4424-8, Article 4424
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DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway
Author / Creator:Bai, Juli ; Cervantes, Christopher ; Liu, Juan ; He, Sijia ; Zhou, Haiyan ; Zhang, Bilin ; Cai, Huan ; Yin, Dongqing ; Hu, Derong ; Li, Zhi ; Chen, Hongzhi ; Gao, Xiaoli ; Wang, Fang ; O’Connor, Jason C. ; Xu, Yong ; Liu, Meilian ; Dong, Lily Q. ; Liu, Feng
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.12196-12201
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STING activator 2′3′‐cGAMP enhanced HSV‐1‐based oncolytic viral therapy
Author / Creator:Sibal, Patricia Angela ; Matsumura, Shigeru ; Ichinose, Toru ; Bustos‐Villalobos, Itzel ; Morimoto, Daishi ; Eissa, Ibrahim R. ; Abdelmoneim, Mohamed ; Aboalela, Mona Alhussein Mostafa ; Mukoyama, Nobuaki ; Tanaka, Maki ; Naoe, Yoshinori ; Kasuya, Hideki
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2024-05, Vol.18 (5), p.1259-1277
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Showing 1 to 20 of 751 results

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Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

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The structural basis for 2′−5′/3′−5′-cGAMP synthesis by cGAS

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cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila

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Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

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Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger

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cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans

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Viruses transfer the antiviral second messenger cGAMP between cells

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Hybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3′, 3′-cGAMP)

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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

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Homogeneous and bioluminescent biochemical and cellular assay for monitoring cGAMP and enzymes that generate and degrade cGAMP

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Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

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Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

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Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

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Transmission of innate immune signaling by packaging of cGAMP in viral particles

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Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

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DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

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STING activator 2′3′‐cGAMP enhanced HSV‐1‐based oncolytic viral therapy

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