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Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo in...

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo in...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26941238

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

About this item

Full title

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (12), p.3329-3334

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Sialic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on glycosylated proteins and lipids. Because of their strategic location at the cell surface, sialic acids contribute to interactions that are critical for immune homeostasis via interactions with sialic acid-binding Ig-type lectins (siglecs). In par...

Alternative Titles

Full title

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_26941238

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26941238

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1507706113

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