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ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-posi...

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-posi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26951678

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

About this item

Full title

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (12), p.E1710-E1719

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The stringent response is a survival mechanism used by bacteria to deal with stress. It is coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival. Although this response has been well characterized in proteobacteria, very little is known about the effe...

Alternative Titles

Full title

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_26951678

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26951678

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1522179113

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