T FH -derived dopamine accelerates productive synapses in germinal centres
T FH -derived dopamine accelerates productive synapses in germinal centres
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Author / Creator
Papa, Ilenia , Saliba, David , Ponzoni, Maurilio , Bustamante, Sonia , Canete, Pablo F , Gonzalez-Figueroa, Paula , McNamara, Hayley A , Valvo, Salvatore , Grimbaldeston, Michele , Sweet, Rebecca A , Vohra, Harpreet , Cockburn, Ian A , Meyer-Hermann, Michael , Dustin, Michael L , Doglioni, Claudio and Vinuesa, Carola G
Publisher
England
Journal title
Language
English
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Publisher
England
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Scope and Contents
Contents
Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (T
) cells in germinal centres. The rapid T-B-cell interactions that occur during this process are reminiscent of neural synaptic transmission pathways. Here we show that a proportion of huma...
Alternative Titles
Full title
T FH -derived dopamine accelerates productive synapses in germinal centres
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Record Identifier
TN_cdi_pubmed_primary_28700579
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_28700579
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E-ISSN
1476-4687
DOI
10.1038/nature23013
