Mettl3-mediated m 6 A regulates spermatogonial differentiation and meiosis initiation
Mettl3-mediated m 6 A regulates spermatogonial differentiation and meiosis initiation
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Author / Creator
Xu, Kai , Yang, Ying , Feng, Gui-Hai , Sun, Bao-Fa , Chen, Jun-Qing , Li, Yu-Fei , Chen, Yu-Sheng , Zhang, Xin-Xin , Wang, Chen-Xin , Jiang, Li-Yuan , Liu, Chao , Zhang, Ze-Yu , Wang, Xiu-Jie , Zhou, Qi , Yang, Yun-Gui and Li, Wei
Publisher
England
Journal title
Language
English
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Publisher
England
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Contents
METTL3 catalyzes the formation of N
-methyl-adenosine (m
A) which has important roles in regulating various biological processes. However, the in vivo function of Mettl3 remains largely unknown in mammals. Here we generated germ cell-specific Mettl3 knockout mice and demonstrated that Mettl3 was essential for male fertility and spermatogenesi...
Alternative Titles
Full title
Mettl3-mediated m 6 A regulates spermatogonial differentiation and meiosis initiation
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Record Identifier
TN_cdi_pubmed_primary_28809392
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_28809392
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E-ISSN
1748-7838
DOI
10.1038/cr.2017.100
