Mechanism of intracellular allosteric β 2 AR antagonist revealed by X-ray crystal structure
Mechanism of intracellular allosteric β 2 AR antagonist revealed by X-ray crystal structure
About this item
Full title
Mechanism of intracellular allosteric β 2 AR antagonist revealed by X-ray crystal structure
Author / Creator
Publisher
England
Journal title
Nature (London), 2017-08, Vol.548 (7668), p.480
Language
English
Formats
Publication information
Publisher
England
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More information
Scope and Contents
Contents
G-protein-coupled receptors (GPCRs) pose challenges for drug discovery efforts because of the high degree of structural homology in the orthosteric pocket, particularly for GPCRs within a single subfamily, such as the nine adrenergic receptors. Allosteric ligands may bind to less-conserved regions of these receptors and therefore are more likely to...
Alternative Titles
Full title
Mechanism of intracellular allosteric β 2 AR antagonist revealed by X-ray crystal structure
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_28813418
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_28813418
Other Identifiers
E-ISSN
1476-4687
DOI
10.1038/nature23652
