C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca 2+ -permeable AMPA receptor-med...
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca 2+ -permeable AMPA receptor-mediated excitotoxicity
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Author / Creator
Selvaraj, Bhuvaneish T , Livesey, Matthew R , Zhao, Chen , Gregory, Jenna M , James, Owain T , Cleary, Elaine M , Chouhan, Amit K , Gane, Angus B , Perkins, Emma M , Dando, Owen , Lillico, Simon G , Lee, Youn-Bok , Nishimura, Agnes L , Poreci, Urjana , Thankamony, Sai , Pray, Meryll , Vasistha, Navneet A , Magnani, Dario , Borooah, Shyamanga , Burr, Karen , Story, David , McCampbell, Alexander , Shaw, Christopher E , Kind, Peter C , Aitman, Timothy J , Whitelaw, C Bruce A , Wilmut, Ian , Smith, Colin , Miles, Gareth B , Hardingham, Giles E , Wyllie, David J A and Chandran, Siddharthan
Publisher
England
Journal title
Language
English
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Publication information
Publisher
England
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Scope and Contents
Contents
Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis (ALS). Here, through a combination of RNA-Seq and electrophysiological studies on induced pluripotent stem cell (iPSC)-derived motor neurons (MNs), we show that increased expression of GluA1 AMPA receptor (AMPAR) subunit occurs in MNs with C9ORF72 mutations tha...
Alternative Titles
Full title
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca 2+ -permeable AMPA receptor-mediated excitotoxicity
Authors, Artists and Contributors
Author / Creator
Livesey, Matthew R
Zhao, Chen
Gregory, Jenna M
James, Owain T
Cleary, Elaine M
Chouhan, Amit K
Gane, Angus B
Perkins, Emma M
Dando, Owen
Lillico, Simon G
Lee, Youn-Bok
Nishimura, Agnes L
Poreci, Urjana
Thankamony, Sai
Pray, Meryll
Vasistha, Navneet A
Magnani, Dario
Borooah, Shyamanga
Burr, Karen
Story, David
McCampbell, Alexander
Shaw, Christopher E
Kind, Peter C
Aitman, Timothy J
Whitelaw, C Bruce A
Wilmut, Ian
Smith, Colin
Miles, Gareth B
Hardingham, Giles E
Wyllie, David J A
Chandran, Siddharthan
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Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_29367641
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_29367641
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02729-0
