TAK-071, a novel M 1 positive allosteric modulator with low cooperativity, improves cognitive functi...
TAK-071, a novel M 1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects
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Publisher
England
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Language
English
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Publisher
England
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Contents
The muscarinic M
receptor (M
R) is a promising target for treating cognitive impairment associated with cholinergic deficits in disorders such as Alzheimer's disease and schizophrenia. We previously reported that cooperativity (α-value) was key to lowering the risk of diarrhea by M
R positive allosteric modulators (M
PAMs). Based on thi...
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TAK-071, a novel M 1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects
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TN_cdi_pubmed_primary_30089885
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_30089885
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E-ISSN
1740-634X
DOI
10.1038/s41386-018-0168-8
