Vitamin B 12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and c...
Vitamin B 12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
About this item
Full title
Author / Creator
Schaffner, Adam , Li, Xianting , Gomez-Llorente, Yacob , Leandrou, Emmanouela , Memou, Anna , Clemente, Nicolina , Yao, Chen , Afsari, Farinaz , Zhi, Lianteng , Pan, Nina , Morohashi, Keita , Hua, Xiaoluan , Zhou, Ming-Ming , Wang, Chunyu , Zhang, Hui , Chen, Shu G , Elliott, Christopher J , Rideout, Hardy , Ubarretxena-Belandia, Iban and Yue, Zhenyu
Publisher
England
Journal title
Language
English
Formats
Publication information
Publisher
England
Subjects
More information
Scope and Contents
Contents
Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therapeutics. Many potent and specific small-molecule LR...
Alternative Titles
Full title
Vitamin B 12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
Authors, Artists and Contributors
Author / Creator
Li, Xianting
Gomez-Llorente, Yacob
Leandrou, Emmanouela
Memou, Anna
Clemente, Nicolina
Yao, Chen
Afsari, Farinaz
Zhi, Lianteng
Pan, Nina
Morohashi, Keita
Hua, Xiaoluan
Zhou, Ming-Ming
Wang, Chunyu
Zhang, Hui
Chen, Shu G
Elliott, Christopher J
Rideout, Hardy
Ubarretxena-Belandia, Iban
Yue, Zhenyu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_30858560
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_30858560
Other Identifiers
E-ISSN
1748-7838
DOI
10.1038/s41422-019-0153-8
