Adaptive plasticity of IL-10 + and IL-35 + T reg cells cooperatively promotes tumor T cell exhaustio...
Adaptive plasticity of IL-10 + and IL-35 + T reg cells cooperatively promotes tumor T cell exhaustion
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Author / Creator
Sawant, Deepali V , Yano, Hiroshi , Chikina, Maria , Zhang, Qianxia , Liao, Mengting , Liu, Chang , Callahan, Derrick J , Sun, Zhe , Sun, Tao , Tabib, Tracy , Pennathur, Arjun , Corry, David B , Luketich, James D , Lafyatis, Robert , Chen, Wei , Poholek, Amanda C , Bruno, Tullia C , Workman, Creg J and Vignali, Dario A A
Publisher
United States
Journal title
Language
English
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Publisher
United States
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Scope and Contents
Contents
Regulatory T cells (T
cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. T
cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expression on tumor-infiltrating lymphocytes (TILs); however, the underlying mediators and mechanisms have remained elusive. Here, we found that t...
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Full title
Adaptive plasticity of IL-10 + and IL-35 + T reg cells cooperatively promotes tumor T cell exhaustion
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Record Identifier
TN_cdi_pubmed_primary_30936494
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_30936494
Other Identifiers
E-ISSN
1529-2916
DOI
10.1038/s41590-019-0346-9
