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Structural plasticity of SARS-CoV-2 3CL M pro active site cavity revealed by room temperature X-ray...

Structural plasticity of SARS-CoV-2 3CL M pro active site cavity revealed by room temperature X-ray...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32581217

Structural plasticity of SARS-CoV-2 3CL M pro active site cavity revealed by room temperature X-ray crystallography

About this item

Full title

Structural plasticity of SARS-CoV-2 3CL M pro active site cavity revealed by room temperature X-ray crystallography

Publisher

England

Journal title

Nature communications, 2020-06, Vol.11 (1), p.3202

Language

English

Formats

Publication information

Publisher

England

More information

Scope and Contents

Contents

The COVID-19 disease caused by the SARS-CoV-2 coronavirus has become a pandemic health crisis. An attractive target for antiviral inhibitors is the main protease 3CL M
due to its essential role in processing the polyproteins translated from viral RNA. Here we report the room temperature X-ray structure of unliganded SARS-CoV-2 3CL M
, reveali...

Alternative Titles

Full title

Structural plasticity of SARS-CoV-2 3CL M pro active site cavity revealed by room temperature X-ray crystallography

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_32581217

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_32581217

Other Identifiers

E-ISSN

2041-1723

DOI

10.1038/s41467-020-16954-7

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