MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylati...
MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP L
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Publisher
England
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Language
English
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England
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Contents
Mind bomb 2 (MIB2) is an E3 ligase involved in Notch signalling and attenuates TNF-induced apoptosis through ubiquitylation of receptor-interacting protein kinase 1 (RIPK1) and cylindromatosis. Here we show that MIB2 bound and conjugated K48- and K63-linked polyubiquitin chains to a long-form of cellular FLICE-inhibitory protein (cFLIP
), a cata...
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Full title
MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP L
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TN_cdi_pubmed_primary_33469115
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33469115
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E-ISSN
2399-3642
DOI
10.1038/s42003-020-01603-y
