L1 retrotransposons exploit RNA m 6 A modification as an evolutionary driving force
L1 retrotransposons exploit RNA m 6 A modification as an evolutionary driving force
About this item
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Author / Creator
Hwang, Sung-Yeon , Jung, Hyunchul , Mun, Seyoung , Lee, Sungwon , Park, Kiwon , Baek, S Chan , Moon, Hyungseok C , Kim, Hyewon , Kim, Baekgyu , Choi, Yongkuk , Go, Young-Hyun , Tang, Wanxiangfu , Choi, Jongsu , Choi, Jung Kyoon , Cha, Hyuk-Jin , Park, Hye Yoon , Liang, Ping , Kim, V Narry , Han, Kyudong and Ahn, Kwangseog
Publisher
England
Journal title
Language
English
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Publication information
Publisher
England
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Scope and Contents
Contents
L1 retrotransposons can pose a threat to genome integrity. The host has evolved to restrict L1 replication. However, mechanisms underlying L1 propagation out of the host surveillance remains unclear. Here, we propose an evolutionary survival strategy of L1, which exploits RNA m
A modification. We discover that m
A 'writer' METTL3 facilitates...
Alternative Titles
Full title
L1 retrotransposons exploit RNA m 6 A modification as an evolutionary driving force
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Record Identifier
TN_cdi_pubmed_primary_33563981
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33563981
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21197-1
