Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H 2 -histamine-receptor activation in...
Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H 2 -histamine-receptor activation in isolated atria of transgenic mice
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Publisher
Germany
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Language
English
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Germany
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Contents
Histamine exerts cAMP-dependent positive inotropic effects (PIE) and positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic mice which overexpress the human H
-receptor in the heart (=H
-TG). To determine whether these effects are antagonized by phosphodiesterases (PDEs), contractile studies were don...
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Full title
Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H 2 -histamine-receptor activation in isolated atria of transgenic mice
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TN_cdi_pubmed_primary_33576869
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_33576869
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E-ISSN
1432-1912
DOI
10.1007/s00210-021-02052-y
