Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas V12 -Induced Cellular Senescence via...
Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas V12 -Induced Cellular Senescence via PGC-1α
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Author / Creator
Yang, Hao , Zhang, Ke , Guo, Yusheng , Guo, Xin , Hou, Kailong , Hou, Jing , Luo, Ying , Liu, Jing and Jia, Shuting
Publisher
Switzerland
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Language
English
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Switzerland
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One of the key steps in tumorigenic transformation is immortalization in which cells bypass cancer-initiating barriers such as senescence. Senescence can be triggered by either telomere erosion or oncogenic stress (oncogene-induced senescence, OIS) and undergo p53- or Rb-dependent cell cycle arrest. The tumor suppressor p53 is mutated in 50% of hum...
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Full title
Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas V12 -Induced Cellular Senescence via PGC-1α
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TN_cdi_pubmed_primary_36835200
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36835200
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E-ISSN
1422-0067
DOI
10.3390/ijms24043790
