Constrained catecholamines gain β 2 AR selectivity through allosteric effects on pocket dynamics
Constrained catecholamines gain β 2 AR selectivity through allosteric effects on pocket dynamics
About this item
Full title
Constrained catecholamines gain β 2 AR selectivity through allosteric effects on pocket dynamics
Author / Creator
Publisher
England
Journal title
Nature communications, 2023-04, Vol.14 (1), p.2138
Language
English
Formats
Publication information
Publisher
England
Subjects
More information
Scope and Contents
Contents
G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to drug development. The amino acids that form the orthosteric binding pocket for epinephrine and norepinephrine in the β
and β
adrenergic receptors (β
AR and β
AR) are identical. Here, to exa...
Alternative Titles
Full title
Constrained catecholamines gain β 2 AR selectivity through allosteric effects on pocket dynamics
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_37059717
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_37059717
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37808-y
