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Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function

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Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_37117223

Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function

About this item

Full title

Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function

Author / Creator

Jami, Sina , Deuis, Jennifer R , Klasfauseweh, Tabea , Cheng, Xiaoyang , Kurdyukov, Sergey , Chung, Felicity , Okorokov, Andrei L , Li, Shengnan , Zhang, Jiangtao , Cristofori-Armstrong, Ben , Israel, Mathilde R , Ju, Robert J , Robinson, Samuel D , Zhao, Peng , Ragnarsson, Lotten , Andersson, Åsa , Tran, Poanna , Schendel, Vanessa , McMahon, Kirsten L , Tran, Hue N T , Chin, Yanni K-Y , Zhu, Yifei , Liu, Junyu , Crawford, Theo , Purushothamvasan, Saipriyaa , Habib, Abdella M , Andersson, David A , Rash, Lachlan D , Wood, John N , Zhao, Jing , Stehbens, Samantha J , Mobli, Mehdi , Leffler, Andreas , Jiang, Daohua , Cox, James J , Waxman, Stephen G , Dib-Hajj, Sulayman D , Neely, G Gregory , Durek, Thomas and Vetter, Irina

Publisher

England

Journal title

Nature communications, 2023-04, Vol.14 (1), p.2442

Language

English

Formats

Articles

Publication information

Publisher

England

Subjects

More information

Scope and Contents

Contents

Voltage-gated sodium (Na
) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, or residues forming part of the pore domain. Excelsatoxin A (ExTxA), a pain-causing knottin peptide from the...

Alternative Titles

Full title

Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_37117223

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_37117223

Other Identifiers

E-ISSN

2041-1723

DOI

10.1038/s41467-023-37963-2

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