Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T reg cells
Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T reg cells
About this item
Full title
Author / Creator
Guan, Xiangnan , Hu, Ruozhen , Choi, Yoonha , Srivats, Shyam , Nabet, Barzin Y , Silva, John , McGinnis, Lisa , Hendricks, Robert , Nutsch, Katherine , Banta, Karl L , Duong, Ellen , Dunkle, Alexis , Chang, Patrick S , Han, Chia-Jung , Mittman, Stephanie , Molden, Nandini , Daggumati, Pallavi , Connolly, Wendy , Johnson, Melissa , Abreu, Delvys Rodriguez , Cho, Byoung Chul , Italiano, Antoine , Gil-Bazo, Ignacio , Felip, Enriqueta , Mellman, Ira , Mariathasan, Sanjeev , Shames, David S , Meng, Raymond , Chiang, Eugene Y , Johnston, Robert J and Patil, Namrata S
Publisher
England
Journal title
Language
English
Formats
Publication information
Publisher
England
Subjects
More information
Scope and Contents
Contents
Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone
. However, there remains little consensus on the mechanism(s) of response with this combination
. Here we find that...
Alternative Titles
Full title
Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T reg cells
Authors, Artists and Contributors
Author / Creator
Hu, Ruozhen
Choi, Yoonha
Srivats, Shyam
Nabet, Barzin Y
Silva, John
McGinnis, Lisa
Hendricks, Robert
Nutsch, Katherine
Banta, Karl L
Duong, Ellen
Dunkle, Alexis
Chang, Patrick S
Han, Chia-Jung
Mittman, Stephanie
Molden, Nandini
Daggumati, Pallavi
Connolly, Wendy
Johnson, Melissa
Abreu, Delvys Rodriguez
Cho, Byoung Chul
Italiano, Antoine
Gil-Bazo, Ignacio
Felip, Enriqueta
Mellman, Ira
Mariathasan, Sanjeev
Shames, David S
Meng, Raymond
Chiang, Eugene Y
Johnston, Robert J
Patil, Namrata S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_38418879
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_38418879
Other Identifiers
E-ISSN
1476-4687
DOI
10.1038/s41586-024-07121-9
