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Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial
Author / Creator:Powles, Thomas ; Kockx, Mark ; Rodriguez-Vida, Alejo ; Duran, Ignacio ; Crabb, Simon J. ; Van Der Heijden, Michiel S. ; Szabados, Bernadett ; Pous, Albert Font ; Gravis, Gwenaelle ; Herranz, Urbano Anido ; Protheroe, Andrew ; Ravaud, Alain ; Maillet, Denis ; Mendez, Maria Jose ; Suarez, Cristina ; Linch, Mark ; Prendergast, Aaron ; van Dam, Pieter-Jan ; Stanoeva, Diana ; Daelemans, Sofie ; Mariathasan, Sanjeev ; Tea, Joy S. ; Mousa, Kelly ; Banchereau, Romain ; Castellano, Daniel
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-11, Vol.25 (11), p.1706-1714
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Molecular determinants of response to PD-L1 blockade across tumor types
Author / Creator:Banchereau, Romain ; Leng, Ning ; Zill, Oliver ; Sokol, Ethan ; Liu, Gengbo ; Pavlick, Dean ; Maund, Sophia ; Liu, Li-Fen ; Kadel, Edward ; Baldwin, Nicole ; Jhunjhunwala, Suchit ; Nickles, Dorothee ; Assaf, Zoe June ; Bower, Daniel ; Patil, Namrata ; McCleland, Mark ; Shames, David ; Molinero, Luciana ; Huseni, Mahrukh ; Sanjabi, Shomyseh ; Cummings, Craig ; Mellman, Ira ; Mariathasan, Sanjeev ; Hegde, Priti ; Powles, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-06, Vol.12 (1), p.3969-3969, Article 3969
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ctDNA guiding adjuvant immunotherapy in urothelial carcinoma
Author / Creator:Powles, Thomas ; Assaf, Zoe June ; Davarpanah, Nicole ; Banchereau, Romain ; Szabados, Bernadett E. ; Yuen, Kobe C. ; Grivas, Petros ; Hussain, Maha ; Oudard, Stephane ; Gschwend, Jürgen E. ; Albers, Peter ; Castellano, Daniel ; Nishiyama, Hiroyuki ; Daneshmand, Siamak ; Sharma, Shruti ; Zimmermann, Bernhard G. ; Sethi, Himanshu ; Aleshin, Alexey ; Perdicchio, Maurizio ; Zhang, Jingbin ; Shames, David S. ; Degaonkar, Viraj ; Shen, Xiaodong ; Carter, Corey ; Bais, Carlos ; Bellmunt, Joaquim ; Mariathasan, Sanjeev
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-07, Vol.595 (7867), p.432-437
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Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial
Author / Creator:Powles, Thomas ; Yuen, Kobe C. ; Gillessen, Silke ; Kadel, Edward E. ; Rathkopf, Dana ; Matsubara, Nobuaki ; Drake, Charles G. ; Fizazi, Karim ; Piulats, Josep M. ; Wysocki, Piotr J. ; Buchschacher, Gary L. ; Alekseev, Boris ; Mellado, Begoña ; Karaszewska, Bogusława ; Doss, Jennifer F. ; Rasuo, Grozdana ; Datye, Asim ; Mariathasan, Sanjeev ; Williams, Patrick ; Sweeney, Christopher J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2022-01, Vol.28 (1), p.144-153
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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Author / Creator:Yuen, Kobe C. ; Liu, Li-Fen ; Gupta, Vinita ; Madireddi, Shravan ; Keerthivasan, Shilpa ; Li, Congfen ; Rishipathak, Deepali ; Williams, Patrick ; Kadel, Edward E. ; Koeppen, Hartmut ; Chen, Ying-Jiun ; Modrusan, Zora ; Grogan, Jane L. ; Banchereau, Romain ; Leng, Ning ; Thastrom, AnnChristine ; Shen, Xiadong ; Hashimoto, Kenji ; Tayama, Darren ; van der Heijden, Michiel S. ; Rosenberg, Jonathan E. ; McDermott, David F. ; Powles, Thomas ; Hegde, Priti S. ; Huseni, Mahrukh A. ; Mariathasan, Sanjeev
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-05, Vol.26 (5), p.693-698
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Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration
Author / Creator:Lim, Yoong Wearn ; Chen-Harris, Haiyin ; Mayba, Oleg ; Lianoglou, Steve ; Wuster, Arthur ; Bhangale, Tushar ; Khan, Zia ; Mariathasan, Sanjeev ; Daemen, Anneleen ; Reeder, Jens ; Haverty, Peter M. ; Forrest, William F. ; Brauer, Matthew ; Mellman, Ira ; Albert, Matthew L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-12, Vol.115 (50), p.E11701-E11710
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Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer
Author / Creator:Khan, Zia ; Di Nucci, Flavia ; Kwan, Antonia ; Hammer, Christian ; Mariathasan, Sanjeev ; Rouilly, Vincent ; Carroll, Jonathan ; Fontes, Magnus ; Acosta, Sergio Ley ; Guardino, Ellie ; Chen-Harris, Haiyin ; Bhangale, Tushar ; Mellman, Ira ; Rosenberg, Jonathan ; Powles, Thomas ; Hunkapiller, Julie ; Chandler, G. Scott ; Albert, Matthew L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-06, Vol.117 (22), p.12288-12294
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ArticlesPeer ReviewedFull Text
Atezolizumab plus chemotherapy versus placebo plus chemotherapy in untreated locally advanced or metastatic urothelial carcinoma (IMvigor130): final overall survival analysis results from a randomised...
Author / Creator:Grande, Enrique, MD ; Arranz, José Á, MD ; De Santis, Maria, MD ; Bamias, Aristotelis, Prof ; Kikuchi, Eiji, Prof ; del Muro, Xavier Garcia, MD ; Park, Se Hoon, Prof ; De Giorgi, Ugo, MD ; Alekseev, Boris, Prof ; Mencinger, Marina, MD ; Izumi, Kouji, MD ; Schutz, Fabio A, MD ; Puente, Javier, MD ; Li, Jian-Ri, MD ; O'Donnell, Peter H, MD ; Kalebasty, Arash Rezazadeh, MD ; Ye, Dingwei, Prof ; Mariathasan, Sanjeev, PhD ; Bene-Tchaleu, FabioIa, MSc ; Bernhard, Sandrine, PharmD ; Lee, Chooi, MD ; Davis, Ian D, Prof ; Galsky, Matthew D, Prof
Publisher:England: Elsevier Limited
Journal title:The lancet oncology, 2024-01, Vol.25 (1), p.29-45
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ArticlesPeer ReviewedFull Text
Atezolizumab monotherapy versus chemotherapy in untreated locally advanced or metastatic urothelial carcinoma (IMvigor130): final overall survival analysis from a randomised, controlled, phase 3 study
Author / Creator:Bamias, Aristotelis, Prof ; Davis, Ian D, Prof ; Galsky, Matthew D, Prof ; Arranz, José Á, MD ; Kikuchi, Eiji, Prof ; Grande, Enrique, MD ; del Muro, Xavier Garcia, MD ; Park, Se Hoon, Prof ; De Giorgi, Ugo, MD ; Alekseev, Boris, MD ; Mencinger, Marina, MD ; Izumi, Kouji, MD ; Schutz, Fabio A, MD ; Puente, Javier, MD ; Li, Jian-Ri, MD ; Panni, Stefano, MD ; Gumus, Mahmut, Prof ; Özgüroğlu, Mustafa, Prof ; Mariathasan, Sanjeev, PhD ; Poloz, Yekaterina, PhD ; Bene-Tchaleu, Fabiola, MSc ; Lee, Chooi, MD ; Bernhard, Sandrine, PharmD ; De Santis, Maria, MD
Publisher:England: Elsevier Limited
Journal title:The lancet oncology, 2024-01, Vol.25 (1), p.46-61
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ArticlesPeer ReviewedFull Text
Cryopyrin activates the inflammasome in response to toxins and ATP
Author / Creator:Mariathasan, Sanjeev ; Weiss, David S. ; Newton, Kim ; McBride, Jacqueline ; O'Rourke, Karen ; Roose-Girma, Meron ; Lee, Wyne P. ; Weinrauch, Yvette ; Monack, Denise M. ; Dixit, Vishva M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2006-03, Vol.440 (7081), p.228-232
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ArticlesPeer ReviewedFull Text
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates
Author / Creator:Staben, Leanna R. ; Koenig, Stefan G. ; Lehar, Sophie M. ; Vandlen, Richard ; Zhang, Donglu ; Chuh, Josefa ; Yu, Shang-Fan ; Ng, Carl ; Guo, Jun ; Liu, Yanzhou ; Fourie-O'Donohue, Aimee ; Go, MaryAnn ; Linghu, Xin ; Segraves, Nathaniel L. ; Wang, Tao ; Chen, Jinhua ; Wei, BinQing ; Phillips, Gail D. Lewis ; Xu, Keyang ; Kozak, Katherine R. ; Mariathasan, Sanjeev ; Flygare, John A. ; Pillow, Thomas H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2016-12, Vol.8 (12), p.1112-1119
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NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide
Author / Creator:Hsu, Li-Chung ; Ali, Syed R ; McGillivray, Shauna ; Tseng, Ping-Hui ; Mariathasan, Sanjeev ; Humke, Eric W ; Eckmann, Lars ; Powell, Jonathan J ; Nizet, Victor ; Dixit, Vishva M ; Karin, Michael
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (22), p.7803-7808
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Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
Author / Creator:Banchereau, Romain ; Chitre, Avantika S. ; Scherl, Alexis ; Wu, Thomas D. ; Patil, Namrata S. ; de Almeida, Patricia ; Kadel, III, Edward E. ; Madireddi, Shravan ; Au-Yeung, Amelia ; Takahashi, Chikara ; Chen, Ying-Jiun ; Modrusan, Zora ; McBride, Jacqueline ; Nersesian, Rhea ; El-Gabry, Ehab A. ; Robida, Mark D. ; Hung, Jeffrey C. ; Kowanetz, Marcin ; Zou, Wei ; McCleland, Mark ; Caplazi, Patrick ; Eshgi, Shadi Toghi ; Koeppen, Hartmut ; Hegde, Priti S. ; Mellman, Ira ; Mathews, W. Rodney ; Powles, Thomas ; Mariathasan, Sanjeev ; Grogan, Jane ; O'Gorman, William E
Publisher:England: BMJ Publishing Group LTD
Journal title:Journal for immunotherapy of cancer, 2021-04, Vol.9 (4), p.e002231
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Analytical validation of a novel comprehensive genomic profiling informed circulating tumor DNA monitoring assay for solid tumors
Author / Creator:Zollinger, Daniel R. ; Rivers, Elizabeth ; Fine, Alexander ; Huang, Yanmei ; Son, Joseph ; Kalyan, Akshita ; Gray, Wren ; Baharian, Golshid ; Hammond, Carly ; Ram, Rosalyn ; Ringman, Lindsay ; Hafez, Dina ; Savel, Daniel ; Patel, Vipul ; Dantone, Marc ; Guo, Cui ; Childress, Merrida ; Xu, Chang ; Johng, Dorhyun ; Wallden, Brett ; Pokharel, Prapti ; Camara, William ; Hegde, Priti S. ; Hughes, Jason ; Carter, Corey ; Davarpanah, Nicole ; Degaonkar, Viraj ; Gupta, Pratyush ; Mariathasan, Sanjeev ; Powles, Thomas ; Ferree, Sean ; Dennis, Lucas ; Young, Amanda
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-05, Vol.19 (5), p.e0302129-e0302129
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ArticlesPeer ReviewedFull Text
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Author / Creator:Mariathasan, Sanjeev ; Newton, Kim ; Monack, Denise M. ; Vucic, Domagoj ; French, Dorothy M. ; Lee, Wyne P. ; Roose-Girma, Meron ; Erickson, Sharon ; Dixit, Vishva M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2004-07, Vol.430 (6996), p.213-218
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ArticlesPeer ReviewedFull Text
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
Author / Creator:Zamboni, Dario S ; Kobayashi, Koichi S ; Kohlsdorf, Tiana ; Ogura, Yasunori ; Long, E Michelle ; Vance, Russell E ; Kuida, Keisuke ; Mariathasan, Sanjeev ; Dixit, Vishva M ; Flavell, Richard A ; Dietrich, William F ; Roy, Craig R
Publisher:New York: Nature Publishing Group US
Journal title:Nature Immunology, 2006-03, Vol.7 (3), p.318-325
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Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
Author / Creator:Fehlings, Michael ; Kim, Leesun ; Guan, Xiangnan ; Yuen, Kobe ; Tafazzol, Alireza ; Sanjabi, Shomyseh ; Zill, Oliver A ; Rishipathak, Deepali ; Wallace, Andrew ; Nardin, Alessandra ; Ma, Siming ; Milojkovic, Ana ; Newell, Evan W ; Mariathasan, Sanjeev ; Yadav, Mahesh
Publisher:London: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2022-08, Vol.10 (8), p.e004759
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ArticlesPeer ReviewedFull Text
Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Author / Creator:Yuen, Kobe C. ; Liu, Li-Fen ; Gupta, Vinita ; Madireddi, Shravan ; Keerthivasan, Shilpa ; Li, Congfen ; Rishipathak, Deepali ; Williams, Patrick ; Kadel, Edward E. ; Koeppen, Hartmut ; Chen, Ying-Jiun ; Modrusan, Zora ; Grogan, Jane L. ; Banchereau, Romain ; Leng, Ning ; Thastrom, AnnChristine ; Shen, Xiadong ; Hashimoto, Kenji ; Tayama, Darren ; van der Heijden, Michiel S. ; Rosenberg, Jonathan E. ; McDermott, David F. ; Powles, Thomas ; Hegde, Priti S. ; Huseni, Mahrukh A. ; Mariathasan, Sanjeev
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2021-03, Vol.27 (3), p.560-560
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ArticlesPeer ReviewedFull Text
Publisher Correction: Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial
Author / Creator:Powles, Thomas ; Kockx, Mark ; Rodriguez-Vida, Alejo ; Duran, Ignacio ; Crabb, Simon J. ; Van Der Heijden, Michiel S. ; Szabados, Bernadett ; Pous, Albert Font ; Gravis, Gwenaelle ; Herranz, Urbano Anido ; Protheroe, Andrew ; Ravaud, Alain ; Maillet, Denis ; Mendez, Maria Jose ; Suarez, Cristina ; Linch, Mark ; Prendergast, Aaron ; van Dam, Pieter-Jan ; Stanoeva, Diana ; Daelemans, Sofie ; Mariathasan, Sanjeev ; Tea, Joy S. ; Mousa, Kelly ; Banchereau, Romain ; Castellano, Daniel
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-06, Vol.26 (6), p.983-983
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445 The relationship between immune-related adverse events (irAEs) and ctDNA status: exploratory analysis from IMvigor010
Author / Creator:Carter, Corey ; Madjar, Katrin ; Balas, Bogdana I ; Essioux, Laurent ; Degaonkar, Viraj ; Mariathasan, Sanjeev ; Scott Chandler, G ; Mohindra, Rajat ; Powles, Thomas
Publisher:London: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A494-A495
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Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

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Molecular determinants of response to PD-L1 blockade across tumor types

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ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

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Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial

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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

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Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

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Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer

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Atezolizumab plus chemotherapy versus placebo plus chemotherapy in untreated locally advanced or metastatic urothelial carcinoma (IMvigor130): final overall survival analysis results from a randomised...

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Atezolizumab monotherapy versus chemotherapy in untreated locally advanced or metastatic urothelial carcinoma (IMvigor130): final overall survival analysis from a randomised, controlled, phase 3 study

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates

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NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

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Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

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Analytical validation of a novel comprehensive genomic profiling informed circulating tumor DNA monitoring assay for solid tumors

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

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Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade

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Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

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Publisher Correction: Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

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445 The relationship between immune-related adverse events (irAEs) and ctDNA status: exploratory analysis from IMvigor010

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