Basic Science and Pathogenesis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_39750910

Basic Science and Pathogenesis

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Author / Creator

De Deyn, Lara , Duchateau, Lena , Watzeels, Tijs , Vicente, Cristina , Van Dongen, Jasper , Bijnens, Baukje , De Pooter, Tim , De Rijk, Peter , Strazisar, Mojca , Vandenberghe, Wim , Thal, Dietmar Rudolf , Mancuso, Renzo , Rademakers, Rosa , Küçükali, Fahri and Sleegers, Kristel

Publisher

United States

Journal title

Alzheimer's & dementia, 2024-12, Vol.20 Suppl 1, p.e092265

Language

English

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Articles

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Publisher

United States

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Contents

ABCA7, an important risk gene for AD, encodes a transporter implicated in lipid transport and phagocytosis, and its disruptions have been linked to AD pathogenesis. However, the impact of these mutations on AD risk is complex due to their interaction with a multifaceted transcriptional architecture and cell type-specificexpression patterns. This st...