Fumarate induces vesicular release of mtDNA to drive innate immunity
Fumarate induces vesicular release of mtDNA to drive innate immunity
About this item
Full title
Author / Creator
Zecchini, Vincent , Paupe, Vincent , Herranz-Montoya, Irene , Janssen, Joëlle , Wortel, Inge M. N. , Morris, Jordan L. , Ferguson, Ashley , Chowdury, Suvagata Roy , Segarra-Mondejar, Marc , Costa, Ana S. H. , Pereira, Gonçalo C. , Tronci, Laura , Young, Timothy , Nikitopoulou, Efterpi , Yang, Ming , Bihary, Dóra , Caicci, Federico , Nagashima, Shun , Speed, Alyson , Bokea, Kalliopi , Baig, Zara , Samarajiwa, Shamith , Tran, Maxine , Mitchell, Thomas , Johnson, Mark , Prudent, Julien and Frezza, Christian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma
1
. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate
2
. However, although the long-term consequences of FH loss have been described, the acute response has not so fa...
Alternative Titles
Full title
Fumarate induces vesicular release of mtDNA to drive innate immunity
Authors, Artists and Contributors
Author / Creator
Paupe, Vincent
Herranz-Montoya, Irene
Janssen, Joëlle
Wortel, Inge M. N.
Morris, Jordan L.
Ferguson, Ashley
Chowdury, Suvagata Roy
Segarra-Mondejar, Marc
Costa, Ana S. H.
Pereira, Gonçalo C.
Tronci, Laura
Young, Timothy
Nikitopoulou, Efterpi
Yang, Ming
Bihary, Dóra
Caicci, Federico
Nagashima, Shun
Speed, Alyson
Bokea, Kalliopi
Baig, Zara
Samarajiwa, Shamith
Tran, Maxine
Mitchell, Thomas
Johnson, Mark
Prudent, Julien
Frezza, Christian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10017517
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10017517
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-023-05770-w
