Urinary tract infections trigger synucleinopathy via the innate immune response
Urinary tract infections trigger synucleinopathy via the innate immune response
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Author / Creator
Peelaerts, Wouter , Mercado, Gabriela , George, Sonia , Villumsen, Marie , Kasen, Alysa , Aguileta, Miguel , Linstow, Christian , Sutter, Alexandra B. , Kuhn, Emily , Stetzik, Lucas , Sheridan, Rachel , Bergkvist, Liza , Meyerdirk, Lindsay , Lindqvist, Allison , Gavis, Martha L. Escobar , Van den Haute, Chris , Hultgren, Scott J. , Baekelandt, Veerle , Pospisilik, J. Andrew , Brudek, Tomasz , Aznar, Susana , Steiner, Jennifer A. , Henderson, Michael X. , Brundin, Lena , Ivanova, Magdalena I. , Hannan, Tom J. and Brundin, Patrik
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Symptoms in the urogenital organs are common in multiple system atrophy (MSA), also in the years preceding the MSA diagnosis. It is unknown how MSA is triggered and these observations in prodromal MSA led us to hypothesize that synucleinopathy could be triggered by infection of the genitourinary tract causing ɑ-synuclein (ɑSyn) to aggregate in peri...
Alternative Titles
Full title
Urinary tract infections trigger synucleinopathy via the innate immune response
Authors, Artists and Contributors
Author / Creator
Mercado, Gabriela
George, Sonia
Villumsen, Marie
Kasen, Alysa
Aguileta, Miguel
Linstow, Christian
Sutter, Alexandra B.
Kuhn, Emily
Stetzik, Lucas
Sheridan, Rachel
Bergkvist, Liza
Meyerdirk, Lindsay
Lindqvist, Allison
Gavis, Martha L. Escobar
Van den Haute, Chris
Hultgren, Scott J.
Baekelandt, Veerle
Pospisilik, J. Andrew
Brudek, Tomasz
Aznar, Susana
Steiner, Jennifer A.
Henderson, Michael X.
Brundin, Lena
Ivanova, Magdalena I.
Hannan, Tom J.
Brundin, Patrik
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10119259
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10119259
Other Identifiers
ISSN
0001-6322,1432-0533
E-ISSN
1432-0533
DOI
10.1007/s00401-023-02562-4