An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
Lung cancer cells overexpress mucin 1 (MUC1) and active subunit MUC1-CT. Although a peptide blocks MUC1 signalling, metabolites targeting MUC1 are not well studied. AICAR is a purine biosynthesis intermediate.
Methods
Cell viability and apoptosis were measured in AICAR-treated
EGFR
-mutant and wild-type lung cells. AICAR-b...
Alternative Titles
Full title
An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10133251
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10133251
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-023-02196-z
