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32 results for Kobayashi,+Susumu+S.

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ArticlesPeer ReviewedFull Text
Targeting transcription factors in acute myeloid leukemia
Author / Creator:Takei, Hisashi ; Kobayashi, Susumu S.
Publisher:Tokyo: Springer Japan
Journal title:International journal of hematology, 2019-01, Vol.109 (1), p.28-34
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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells
Author / Creator:Fujimoto, Yumi ; Morita, Tomoko Yamamori ; Ohashi, Akihiro ; Haeno, Hiroshi ; Hakozaki, Yumi ; Fujii, Masanori ; Kashima, Yukie ; Kobayashi, Susumu S. ; Mukohara, Toru
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-12, Vol.10 (1), p.21762-21762, Article 21762
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AXL activates YAP through the EGFR–LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma
Author / Creator:Okamoto, Kento ; Ando, Toshinori ; Izumi, Hiroki ; Kobayashi, Susumu S. ; Shintani, Tomoaki ; Gutkind, J. Silvio ; Yanamoto, Souichi ; Miyauchi, Mutsumi ; Kajiya, Mikihito
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2023-09, Vol.42 (39), p.2869-2877
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TAS2940, a novel brain‐penetrable pan‐ERBB inhibitor, for tumors with HER2 and EGFR aberrations
Author / Creator:Oguchi, Kei ; Araki, Hikari ; Tsuji, Shingo ; Nakamura, Masayuki ; Miura, Akihiro ; Funabashi, Kaoru ; Osada, Akiko ; Tanaka, Sakiho ; Suzuki, Takamasa ; Kobayashi, Susumu S. ; Mizuarai, Shinji
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2023-02, Vol.114 (2), p.654-664
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ArticlesPeer ReviewedFull Text
NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells
Author / Creator:de Miranda, Lívia Bassani Lins ; Lima, Keli ; Coelho-Silva, Juan Luiz ; Traina, Fabiola ; Kobayashi, Susumu S. ; Machado-Neto, João Agostinho
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-10, Vol.12 (1), p.17092-17092, Article 17092
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Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer
Author / Creator:Izumi, Motohiro ; Fujii, Masanori ; Kobayashi, Ikei S. ; Ho, Vivian ; Kashima, Yukie ; Udagawa, Hibiki ; Costa, Daniel B. ; Kobayashi, Susumu S.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2024-08, Vol.15 (8), p.580-11, Article 580
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ArticlesPeer ReviewedFull Text
TIP60 is required for tumorigenesis in non‐small cell lung cancer
Author / Creator:Shibahara, Daisuke ; Akanuma, Naoki ; Kobayashi, Ikei S. ; Heo, Eunyoung ; Ando, Mariko ; Fujii, Masanori ; Jiang, Feng ; Prin, P. Nicholas ; Pan, Gilbert ; Wong, Kwok‐Kin ; Costa, Daniel B. ; Bararia, Deepak ; Tenen, Daniel G. ; Watanabe, Hideo ; Kobayashi, Susumu S.
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2023-06, Vol.114 (6), p.2400-2413
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Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms
Author / Creator:Takei, Hisashi ; Coelho‐Silva, Juan Luiz ; Tavares Leal, Cristina ; Queiroz Arantes Rocha, Adriana ; Mantello Bianco, Thiago ; Welner, Robert S. ; Mishima, Yuta ; Kobayashi, Ikei S. ; Mullally, Ann ; Lima, Keli ; Machado‐Neto, João Agostinho ; Kobayashi, Susumu S. ; Lobo de Figueiredo‐Pontes, Lorena
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2022-02, Vol.113 (2), p.597-608
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ArticlesPeer ReviewedFull Text
Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator
Author / Creator:Takei, Hisashi ; Fukuda, Hirofumi ; Pan, Gilbert ; Yamazaki, Hiroyuki ; Matsumoto, Tadahiko ; Kazuma, Yasuhiro ; Fujii, Masanori ; Nakayama, Sohei ; Kobayashi, Ikei S. ; Shindo, Keisuke ; Yamashita, Riu ; Shirakawa, Kotaro ; Takaori-Kondo, Akifumi ; Kobayashi, Susumu S.
Publisher:Singapore: Springer Singapore
Journal title:International journal of hematology, 2020-09, Vol.112 (3), p.395-408
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ArticlesPeer ReviewedFull Text
HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs
Author / Creator:Watanabe, Sho ; Goto, Yasushi ; Yasuda, Hiroyuki ; Kohno, Takashi ; Motoi, Noriko ; Ohe, Yuichiro ; Nishikawa, Hiroyoshi ; Kobayashi, Susumu S. ; Kuwano, Kazuyoshi ; Togashi, Yosuke
Publisher:Melbourne: John Wiley & Sons Australia, Ltd
Journal title:Thoracic cancer, 2021-03, Vol.12 (5), p.631-642
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ArticlesPeer ReviewedFull Text
Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα
Author / Creator:Sridhar, Radhakrishnan ; Takei, Hisashi ; Syed, Riyaz ; Kobayashi, Ikei S. ; Hui, Liu Bee ; Kamal, Ahmed ; Tenen, Daniel G. ; Kobayashi, Susumu S.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-08, Vol.23 (8), p.1938
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ArticlesPeer ReviewedFull Text
EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active Inhibitors in Precl...
Author / Creator:Kobayashi, Ikei ; Viray, Hollis ; Rangachari, Deepa ; Kobayashi, Susumu ; Costa, Daniel
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-12, Vol.10 (12), p.3561
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NAD Modulates DNA Methylation and Cell Differentiation
Author / Creator:Ummarino, Simone ; Hausman, Clinton ; Gaggi, Giulia ; Rinaldi, Lucrezia ; Bassal, Mahmoud A. ; Zhang, Yanzhou ; Seelam, Andy Joe ; Kobayashi, Ikei S. ; Borchiellini, Marta ; Ebralidze, Alexander K. ; Ghinassi, Barbara ; Trinh, Bon Q. ; Kobayashi, Susumu S. ; Di Ruscio, Annalisa
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-11, Vol.10 (11), p.2986
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ArticlesPeer ReviewedFull Text
LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion
Author / Creator:Mori, Shunta ; Izumi, Hiroki ; Araki, Mitsugu ; Liu, Jie ; Tanaka, Yu ; Kagawa, Yosuke ; Sagae, Yukari ; Ma, Biao ; Isaka, Yuta ; Sasakura, Yoko ; Kumagai, Shogo ; Sakae, Yuta ; Tanaka, Kosuke ; Shibata, Yuji ; Udagawa, Hibiki ; Matsumoto, Shingo ; Yoh, Kiyotaka ; Okuno, Yasushi ; Goto, Koichi ; Kobayashi, Susumu S.
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2024-04, Vol.7 (1), p.412-10, Article 412
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CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma
Author / Creator:Cai, Yi ; Hirata, Ayako ; Nakayama, Sohei ; VanderLaan, Paul A. ; Levantini, Elena ; Yamamoto, Mihoko ; Hirai, Hideyo ; Wong, Kwok-Kin ; Costa, Daniel B. ; Watanabe, Hideo ; Kobayashi, Susumu S.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0120647
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The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer
Author / Creator:Izumi, Hiroki ; Matsumoto, Shingo ; Liu, Jie ; Tanaka, Kosuke ; Mori, Shunta ; Hayashi, Kumiko ; Kumagai, Shogo ; Shibata, Yuji ; Hayashida, Takuma ; Watanabe, Kana ; Fukuhara, Tatsuro ; Ikeda, Takaya ; Yoh, Kiyotaka ; Kato, Terufumi ; Nishino, Kazumi ; Nakamura, Atsushi ; Nakachi, Ichiro ; Kuyama, Shoichi ; Furuya, Naoki ; Sakakibara-Konishi, Jun ; Okamoto, Isamu ; Taima, Kageaki ; Ebi, Noriyuki ; Daga, Haruko ; Yamasaki, Akira ; Kodani, Masahiro ; Udagawa, Hibiki ; Kirita, Keisuke ; Zenke, Yoshitaka ; Nosaki, Kaname ; Sugiyama, Eri ; Sakai, Tetsuya ; Nakai, Tokiko ; Ishii, Genichiro ; Niho, Seiji ; Ohtsu, Atsushi ; Kobayashi, Susumu S. ; Goto, Koichi
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-12, Vol.600 (7888), p.319-323
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ArticlesPeer ReviewedFull Text
Clinical Benefit of Tyrosine Kinase Inhibitors in Advanced Lung Cancer with EGFR‐G719A and Other Uncommon EGFR Mutations
Author / Creator:Sehgal, Kartik ; Rangachari, Deepa ; VanderLaan, Paul A. ; Kobayashi, Susumu S. ; Costa, Daniel B.
Publisher:Hoboken, USA: John Wiley & Sons, Inc
Journal title:The oncologist (Dayton, Ohio), 2021-04, Vol.26 (4), p.281-287
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An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
Author / Creator:Aftab, Fareesa ; Rodriguez-Fuguet, Alice ; Silva, Luis ; Kobayashi, Ikei S. ; Sun, Jiao ; Politi, Katerina ; Levantini, Elena ; Zhang, Wei ; Kobayashi, Susumu S. ; Zhang, Wen Cai
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2023-05, Vol.128 (9), p.1647-1664
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A Real-World Study of Patient Characteristics and Clinical Outcomes in EGFR Mutated Lung Cancer Treated with First-Line Osimertinib: Expanding the FLAURA Trial Results into Routine Clinical Practice
Author / Creator:Viray, Hollis ; Piper-Vallillo, Andrew J. ; Widick, Page ; Academia, Emmeline ; Shea, Meghan ; Rangachari, Deepa ; VanderLaan, Paul A. ; Kobayashi, Susumu S. ; Costa, Daniel B.
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2024-03, Vol.16 (6), p.1079
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Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations
Author / Creator:Ikemura, Shinnosuke ; Yasuda, Hiroyuki ; Matsumoto, Shingo ; Kamada, Mayumi ; Hamamoto, Junko ; Masuzawa, Keita ; Kobayashi, Keigo ; Manabe, Tadashi ; Arai, Daisuke ; Nakachi, Ichiro ; Kawada, Ichiro ; Ishioka, Kota ; Nakamura, Morio ; Namkoong, Ho ; Naoki, Katsuhiko ; Ono, Fumie ; Araki, Mitsugu ; Kanada, Ryo ; Ma, Biao ; Hayashi, Yuichiro ; Mimaki, Sachiyo ; Yoh, Kiyotaka ; Kobayashi, Susumu S. ; Kohno, Takashi ; Okuno, Yasushi ; Goto, Koichi ; Tsuchihara, Katsuya ; Soejima, Kenzo
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (20), p.10025-10030
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Showing 1 to 20 of 32 results

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Targeting transcription factors in acute myeloid leukemia

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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

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AXL activates YAP through the EGFR–LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma

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TAS2940, a novel brain‐penetrable pan‐ERBB inhibitor, for tumors with HER2 and EGFR aberrations

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NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells

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Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer

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TIP60 is required for tumorigenesis in non‐small cell lung cancer

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Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms

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Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator

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HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs

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Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα

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EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active Inhibitors in Precl...

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NAD Modulates DNA Methylation and Cell Differentiation

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LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion

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CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma

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The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer

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Clinical Benefit of Tyrosine Kinase Inhibitors in Advanced Lung Cancer with EGFR‐G719A and Other Uncommon EGFR Mutations

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An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1

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A Real-World Study of Patient Characteristics and Clinical Outcomes in EGFR Mutated Lung Cancer Treated with First-Line Osimertinib: Expanding the FLAURA Trial Results into Routine Clinical Practice

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Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

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