Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia i...
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models
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Full title
Author / Creator
Dejanovic, Borislav , Wu, Tiffany , Tsai, Ming-Chi , Graykowski, David , Gandham, Vineela D , Rose, Christopher M , Bakalarski, Corey E , Ngu, Hai , Wang, Yuanyuan , Pandey, Shristi , Rezzonico, Mitchell G , Friedman, Brad A , Edmonds, Rose , De Mazière, Ann , Rakosi-Schmidt, Raphael , Singh, Tarjinder , Klumperman, Judith , Foreman, Oded , Chang, Michael C , Xie, Luke , Sheng, Morgan and Hanson, Jesse E
Publisher
United States: Nature Publishing Group
Journal title
Language
English
Formats
Publication information
Publisher
United States: Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in Tau
synapse fractions with age and in a C1q-dependent manner. In addition to microglia, we identified that astrocytes contribute substantially to synapse el...
Alternative Titles
Full title
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models
Authors, Artists and Contributors
Author / Creator
Wu, Tiffany
Tsai, Ming-Chi
Graykowski, David
Gandham, Vineela D
Rose, Christopher M
Bakalarski, Corey E
Ngu, Hai
Wang, Yuanyuan
Pandey, Shristi
Rezzonico, Mitchell G
Friedman, Brad A
Edmonds, Rose
De Mazière, Ann
Rakosi-Schmidt, Raphael
Singh, Tarjinder
Klumperman, Judith
Foreman, Oded
Chang, Michael C
Xie, Luke
Sheng, Morgan
Hanson, Jesse E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154216
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154216
Other Identifiers
ISSN
2662-8465
E-ISSN
2662-8465
DOI
10.1038/s43587-022-00281-1
