Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic ce...
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells
About this item
Full title
Author / Creator
Oltra, Sara S. , Colomo, Sara , Sin, Laura , Pérez-López, María , Lázaro, Sara , Molina-Crespo, Angela , Choi, Kyoung-Han , Ros-Pardo, David , Martínez, Lidia , Morales, Saleta , González-Paramos, Cristina , Orantes, Alba , Soriano, Mario , Hernández, Alberto , Lluch, Ana , Rojo, Federico , Albanell, Joan , Gómez-Puertas, Paulino , Ko, Jae-Kyun , Sarrió, David and Moreno-Bueno, Gema
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but Gasdermin-B (GSDMB) exhibit cell death-dependent and independent activities in several pathologies including cancer. When the GSDMB pore-forming N-terminal domain is released by Granzyme-A cleavage, it provokes cancer cell death, but uncleaved GSDMB promotes mul...
Alternative Titles
Full title
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells
Authors, Artists and Contributors
Author / Creator
Colomo, Sara
Sin, Laura
Pérez-López, María
Lázaro, Sara
Molina-Crespo, Angela
Choi, Kyoung-Han
Ros-Pardo, David
Martínez, Lidia
Morales, Saleta
González-Paramos, Cristina
Orantes, Alba
Soriano, Mario
Hernández, Alberto
Lluch, Ana
Rojo, Federico
Albanell, Joan
Gómez-Puertas, Paulino
Ko, Jae-Kyun
Sarrió, David
Moreno-Bueno, Gema
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154425
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154425
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-023-01143-y
