Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of func...
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation
About this item
Full title
Author / Creator
Filipello, Fabia , You, Shih-Feng , Mirfakhar, Farzaneh S. , Mahali, Sidhartha , Bollman, Bryan , Acquarone, Mariana , Korvatska, Olena , Marsh, Jacob A. , Sivaraman, Anirudh , Martinez, Rita , Cantoni, Claudia , De Feo, Luca , Ghezzi, Laura , Minaya, Miguel A. , Renganathan, Arun , Cashikar, Anil G. , Satoh, Jun-Ichi , Beatty, Wandy , Iyer, Abhirami K. , Cella, Marina , Raskind, Wendy H. , Piccio, Laura and Karch, Celeste M.
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the
TREM2
gene has been implicated in risk for Alzheimer’s disease and frontotemporal dementia, while homozygous
TREM2
mutations cause a rare leukodystrophy, Nasu-Hakola disease (NHD). Despite extensive investigation, the role of TREM2 in...
Alternative Titles
Full title
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation
Authors, Artists and Contributors
Author / Creator
You, Shih-Feng
Mirfakhar, Farzaneh S.
Mahali, Sidhartha
Bollman, Bryan
Acquarone, Mariana
Korvatska, Olena
Marsh, Jacob A.
Sivaraman, Anirudh
Martinez, Rita
Cantoni, Claudia
De Feo, Luca
Ghezzi, Laura
Minaya, Miguel A.
Renganathan, Arun
Cashikar, Anil G.
Satoh, Jun-Ichi
Beatty, Wandy
Iyer, Abhirami K.
Cella, Marina
Raskind, Wendy H.
Piccio, Laura
Karch, Celeste M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10175346
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10175346
Other Identifiers
ISSN
0001-6322,1432-0533
E-ISSN
1432-0533
DOI
10.1007/s00401-023-02568-y
