Mind the Curve: Dose-Response Fitting Biases the Synergy Scores across Software Used for Chemotherap...
Mind the Curve: Dose-Response Fitting Biases the Synergy Scores across Software Used for Chemotherapy Combination Studies
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Publisher
Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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Drug combinations are increasingly studied in the field of anticancer agents. Mathematical models, such as Loewe, Bliss, and HSA, are used to interpret drug combinations, while informatics tools help cancer researchers identify the most effective combinations. However, the different algorithms each software uses lead to results that do not always c...
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Mind the Curve: Dose-Response Fitting Biases the Synergy Scores across Software Used for Chemotherapy Combination Studies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10253300
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10253300
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms24119705
