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Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with PSC and IBD, and these patients are at a much greater risk compared to patients with IBD without concomitant PSC. Combin...

Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis

10.1038/s41591-023-02372-x