Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for imm...
Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy
About this item
Full title
Author / Creator
Davern, Maria , Donlon, Noel E. , O’Connell, Fiona , Gaughan, Caoimhe , O’Donovan, Cillian , McGrath, Jason , Sheppard, Andrew D. , Hayes, Conall , King, Ross , Temperley, Hugo , MacLean, Michael , Bulter, Christine , Bhardwaj, Anshul , Moore, Jenny , Donohoe, Claire , Ravi, Narayanasamy , Conroy, Melissa J. , Reynolds, John V. and Lysaght, Joanne
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Aim
Use of immune checkpoint blockade to enhance T cell-mediated immunity within the hostile tumour microenvironment (TME) is an attractive approach in oesophageal adenocarcinoma (OAC). This study explored the effects of the hostile TME, including nutrient deprivation and hypoxia, on immune checkpoint (IC) expression and T cell phenotypes, and t...
Alternative Titles
Full title
Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy
Authors, Artists and Contributors
Author / Creator
Donlon, Noel E.
O’Connell, Fiona
Gaughan, Caoimhe
O’Donovan, Cillian
McGrath, Jason
Sheppard, Andrew D.
Hayes, Conall
King, Ross
Temperley, Hugo
MacLean, Michael
Bulter, Christine
Bhardwaj, Anshul
Moore, Jenny
Donohoe, Claire
Ravi, Narayanasamy
Conroy, Melissa J.
Reynolds, John V.
Lysaght, Joanne
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10349772
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10349772
Other Identifiers
ISSN
0171-5216
E-ISSN
1432-1335
DOI
10.1007/s00432-022-04440-0
