Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
About this item
Full title
Author / Creator
Miguez, Andrés , Gomis, Cinta , Vila, Cristina , Monguió-Tortajada, Marta , Fernández-García, Sara , Bombau, Georgina , Galofré, Mireia , García-Bravo, María , Sanders, Phil , Fernández-Medina, Helena , Poquet, Blanca , Salado-Manzano, Cristina , Roura, Santiago , Alberch, Jordi , Segovia, José Carlos , Allen, Nicholas D. , Borràs, Francesc E. and Canals, Josep M.
Publisher
Cham: Springer International Publishing
Journal title
Language
English
Formats
Publication information
Publisher
Cham: Springer International Publishing
Subjects
More information
Scope and Contents
Contents
Huntington's disease (HD) is an incurable inherited brain disorder characterised by massive degeneration of striatal neurons, which correlates with abnormal accumulation of misfolded mutant huntingtin (mHTT) protein. Research on HD has been hampered by the inability to study early dysfunction and progressive degeneration of human striatal neurons i...
Alternative Titles
Full title
Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
Authors, Artists and Contributors
Author / Creator
Gomis, Cinta
Vila, Cristina
Monguió-Tortajada, Marta
Fernández-García, Sara
Bombau, Georgina
Galofré, Mireia
García-Bravo, María
Sanders, Phil
Fernández-Medina, Helena
Poquet, Blanca
Salado-Manzano, Cristina
Roura, Santiago
Alberch, Jordi
Segovia, José Carlos
Allen, Nicholas D.
Borràs, Francesc E.
Canals, Josep M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10400696
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10400696
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-023-04882-w
