Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure...
Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension
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Author / Creator
Mathieu, Natalia M , Fekete, Eva M , Muskus, Patricia C , Brozoski, Daniel T , Lu, Ko-Ting , Wackman, Kelsey K , Gomez, Javier , Fang, Shi , Reho, John J , Grobe, Connie C , Vazirabad, Ibrahim , Mouradian, Gary C , Hodges, Matthew R , Segar, Jeffrey L , Grobe, Justin L , Sigmund, Curt D and Nakagawa, Pablo
Publisher
England: Oxford University Press
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Language
English
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Publisher
England: Oxford University Press
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Abstract
Non-enzymatic activation of renin via its interaction with prorenin receptor (PRR) has been proposed as a key mechanism of local renin–angiotensin system (RAS) activation. The presence of renin and angiotensinogen has been reported in the rostral ventrolateral medulla (RVLM). Overactivation of bulbospinal neurons in the RVLM is linked t...
Alternative Titles
Full title
Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10440998
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10440998
Other Identifiers
ISSN
2633-8823
E-ISSN
2633-8823
DOI
10.1093/function/zqad043
