IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammat...
IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice
About this item
Full title
Author / Creator
Andreadou, Myrto , Ingelfinger, Florian , De Feo, Donatella , Cramer, Teresa L. M. , Tuzlak, Selma , Friebel, Ekaterina , Schreiner, Bettina , Eede, Pascale , Schneeberger, Shirin , Geesdorf, Maria , Ridder, Frederike , Welsh, Christina A. , Power, Laura , Kirschenbaum, Daniel , Tyagarajan, Shiva K. , Greter, Melanie , Heppner, Frank L. , Mundt, Sarah and Becher, Burkhard
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in autoimmune conditions, including of the CNS, IL-12 reduces inflammation. The underlying mechanism behind these opposing properties and the involved cellular players remain elusive. Here we map IL-12 receptor (IL-12R) expression to NK and T cells as well as neurons and o...
Alternative Titles
Full title
IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice
Authors, Artists and Contributors
Author / Creator
Ingelfinger, Florian
De Feo, Donatella
Cramer, Teresa L. M.
Tuzlak, Selma
Friebel, Ekaterina
Schreiner, Bettina
Eede, Pascale
Schneeberger, Shirin
Geesdorf, Maria
Ridder, Frederike
Welsh, Christina A.
Power, Laura
Kirschenbaum, Daniel
Tyagarajan, Shiva K.
Greter, Melanie
Heppner, Frank L.
Mundt, Sarah
Becher, Burkhard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10545539
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10545539
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-023-01435-z
