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CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering

CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10583764

CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering

About this item

Full title

CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering

Publisher

New York: Nature Publishing Group US

Journal title

Nature biotechnology, 2021-04, Vol.39 (4), p.480-489

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Existing technologies for site-specific integration of kilobase-sized DNA sequences in bacteria are limited by low efficiency, a reliance on recombination, the need for multiple vectors, and challenges in multiplexing. To address these shortcomings, we introduce a substantially improved version of our previously reported Tn
7
-like transposon...

Alternative Titles

Full title

CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10583764

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10583764

Other Identifiers

ISSN

1087-0156

E-ISSN

1546-1696

DOI

10.1038/s41587-020-00745-y

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