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Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth...

Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10709146

Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor

About this item

Full title

Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor

Publisher

London: Nature Publishing Group UK

Journal title

Nature cell biology, 2023-12, Vol.25 (12), p.1746-1757

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this is regulated. Here we found that nerve growth factor (NGF) produced by leptin receptor-expressing (LepR
+
) stromal cells is required to maintain nerve fibres in adult bone m...

Alternative Titles

Full title

Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10709146

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10709146

Other Identifiers

ISSN

1465-7392

E-ISSN

1476-4679

DOI

10.1038/s41556-023-01284-9

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