Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity
Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity
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Author / Creator
Li, Yongsheng , Shen, Zhiyong , Chai, Zhen , Zhan, Yizhi , Zhang, Yaowei , Liu, Zhengyu , Liu, Yuechen , Li, Zhenkang , Lin, Mingdao , Zhang, Zhanqiao , Liu, Wei , Guan, Shenyuan , Zhang, Jinchao , Qian, Junying , Ding, Yi , Li, Guoxin , Fang, Yuan and Deng, Haijun
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
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Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
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Scope and Contents
Contents
ObjectiveCheckpoint immunotherapy unleashes T-cell control of tumours but is suppressed by immunosuppressive myeloid cells. The transmembrane protein MS4A4A is selectively highly expressed in tumour-associated macrophages (TAMs). Here, we aimed to reveal the role of MS4A4A+ TAMs in regulating the immune escape of tumour cells and to develop novel t...
Alternative Titles
Full title
Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10715532
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10715532
Other Identifiers
ISSN
0017-5749,1468-3288
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2022-329147
