Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate ligand binding, aided by co-chaperones. In vivo, the co-chaperones FKBP51 and FKBP52 antagonistical...
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Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10716051
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10716051
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-023-01128-y
