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cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement

cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10730389

cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement

About this item

Full title

cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement

Publisher

London: Nature Publishing Group UK

Journal title

Molecular psychiatry, 2023-09, Vol.28 (9), p.3930-3942

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Chronic cocaine exposure induces enduring neuroadaptations that facilitate motivated drug taking. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to modulate neuronal firing and pacemaker activity in ventral tegmental area (VTA) dopamine neurons. However, it remained unknown whether cocaine self-administration affects H...

Alternative Titles

Full title

cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10730389

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10730389

Other Identifiers

ISSN

1359-4184

E-ISSN

1476-5578

DOI

10.1038/s41380-023-02290-x

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