Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robu...
Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness
About this item
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
How enhancers activate their distal target promoters remains incompletely understood. Here we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions. Using an allelic series of mouse mutants, we show that CTCF is neither required for the interaction of the
Sox2
gene with distal enhancers, nor for its expression....
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Full title
Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10758292
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10758292
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-022-01295-6
