Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
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Full title
Author / Creator
Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network , Kang, Joyce B. , Shen, Amber Z. , Gurajala, Saisriram , Nathan, Aparna , Rumker, Laurie , Aguiar, Vitor R. C. , Valencia, Cristian , Lagattuta, Kaitlyn A. , Zhang, Fan , Jonsson, Anna Helena , Yazar, Seyhan , Alquicira-Hernandez, Jose , Khalili, Hamed , Ananthakrishnan, Ashwin N. , Jagadeesh, Karthik , Dey, Kushal , Daly, Mark J. , Xavier, Ramnik J. , Donlin, Laura T. , Anolik, Jennifer H. , Powell, Joseph E. , Rao, Deepak A. , Brenner, Michael B. , Gutierrez-Arcelus, Maria , Luo, Yang , Sakaue, Saori and Raychaudhuri, Soumya
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. While coding variation in
HLA
genes has been extensively documented, regulatory genetic variation modulating
HLA
expression levels has not been comprehensively investigated. Here we map...
Alternative Titles
Full title
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
Authors, Artists and Contributors
Author / Creator
Kang, Joyce B.
Shen, Amber Z.
Gurajala, Saisriram
Nathan, Aparna
Rumker, Laurie
Aguiar, Vitor R. C.
Valencia, Cristian
Lagattuta, Kaitlyn A.
Zhang, Fan
Jonsson, Anna Helena
Yazar, Seyhan
Alquicira-Hernandez, Jose
Khalili, Hamed
Ananthakrishnan, Ashwin N.
Jagadeesh, Karthik
Dey, Kushal
Daly, Mark J.
Xavier, Ramnik J.
Donlin, Laura T.
Anolik, Jennifer H.
Powell, Joseph E.
Rao, Deepak A.
Brenner, Michael B.
Gutierrez-Arcelus, Maria
Luo, Yang
Sakaue, Saori
Raychaudhuri, Soumya
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10787945
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10787945
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-023-01586-6
