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Systems engineering of Escherichia coli for high-level glutarate production from glucose

Systems engineering of Escherichia coli for high-level glutarate production from glucose

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10838341

Systems engineering of Escherichia coli for high-level glutarate production from glucose

About this item

Full title

Systems engineering of Escherichia coli for high-level glutarate production from glucose

Publisher

England: Nature Publishing Group UK

Journal title

Nature communications, 2024-02, Vol.15 (1), p.1032

Language

English

Formats

Publication information

Publisher

England: Nature Publishing Group UK

More information

Scope and Contents

Contents

Glutarate is a key monomer in polyester and polyamide production. The low efficiency of the current biosynthetic pathways hampers its production by microbial cell factories. Herein, through metabolic simulation, a lysine-overproducing E. coli strain Lys5 is engineered, achieving titer, yield, and productivity of 195.9 g/L, 0.67 g/g glucose, and 5.4...

Alternative Titles

Full title

Systems engineering of Escherichia coli for high-level glutarate production from glucose

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10838341

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10838341

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-45448-z

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