An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
Skp1‐Cdc53/Cul1‐F‐box (SCF) complexes constitute a class of E3 ubiquitin ligases. Recently, a multiprotein complex containing pVHL, elongin C and Cul2 (VEC) was shown to structurally and functionally resemble SCF complexes. Cdc53 and the Cullins can become covalently linked to the ubiquitin‐like molecule Rub1/NEDD8. Inhibition of neddylation inhibi...
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Full title
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1083969
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1083969
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ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1093/embo-reports/kvf028
