Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F a...
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms
About this item
Full title
Author / Creator
Guo, Jing , Walter, Klaudia , Quiros, Pedro M. , Gu, Muxin , Baxter, E. Joanna , Danesh, John , Di Angelantonio, Emanuele , Roberts, David , Guglielmelli, Paola , Harrison, Claire N. , Godfrey, Anna L. , Green, Anthony R. , Vassiliou, George S. , Vuckovic, Dragana , Nangalia, Jyoti and Soranzo, Nicole
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction of mature blood cells. Their causative somatic mutations, for example,
JAK2
V617F
, are common in the population, yet only a minority of carriers develop MPN. Here we show that the inherited polygenic loci that underlie common hematological traits influ...
Alternative Titles
Full title
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10864174
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10864174
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-023-01638-x
