Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular re...
Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling
About this item
Full title
Author / Creator
Lin, Susan M , Rue, Ryan , Mukhitov, Alexander R , Goel, Akansha , Basil, Maria C , Obraztsova, Kseniya , Babu, Apoorva , Crnkovic, Slaven , Ledwell, Owen , Ferguson, Laura T , Planer, Joseph D , Nottingham, Ana N , Vanka, Kanth Swaroop , Smith, Carly J , Cantu Iii, Edward , Kwapiszewska, Grazyna , Morrisey, Edward E , Evans, Jillian F and Krymskaya, Vera P
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease caused by tuberous sclerosis complex 1/2 (TSC1/2) gene mutations in pulmonary mesenchymal cells resulting in activation of the mechanistic target of rapamycin complex 1 (mTORC1). A subset of LAM patients develops pulmonary vascular remodeling and pulmonary hypertension. Little, how...
Alternative Titles
Full title
Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling
Authors, Artists and Contributors
Author / Creator
Rue, Ryan
Mukhitov, Alexander R
Goel, Akansha
Basil, Maria C
Obraztsova, Kseniya
Babu, Apoorva
Crnkovic, Slaven
Ledwell, Owen
Ferguson, Laura T
Planer, Joseph D
Nottingham, Ana N
Vanka, Kanth Swaroop
Smith, Carly J
Cantu Iii, Edward
Kwapiszewska, Grazyna
Morrisey, Edward E
Evans, Jillian F
Krymskaya, Vera P
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10866655
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10866655
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI172116
