Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation
Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation
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Author / Creator
Hartmann, Philipp , Bohdan, Kostiantyn , Hommrich, Moritz , Juliá, Fabio , Vogelsang, Lara , Eirich, Jürgen , Zangl, Rene , Farès, Christophe , Jacobs, Julia Beatrice , Mukhopadhyay, Dwaipayan , Mengeler, Johanna Marie , Vetere, Alessandro , Sterling, Marie Sophie , Hinrichs, Heike , Becker, Stefan , Morgner, Nina , Schrader, Wolfgang , Finkemeier, Iris , Dietz, Karl-Josef , Griesinger, Christian and Ritter, Tobias
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cysteine conjugation is an important tool in protein research and relies on fast, mild and chemoselective reactions. Cysteinyl thiols can either be modified with prefunctionalized electrophiles, or converted into electrophiles themselves for functionalization with selected nucleophiles in an independent step. Here we report a bioconjugation strateg...
Alternative Titles
Full title
Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation
Authors, Artists and Contributors
Author / Creator
Bohdan, Kostiantyn
Hommrich, Moritz
Juliá, Fabio
Vogelsang, Lara
Eirich, Jürgen
Zangl, Rene
Farès, Christophe
Jacobs, Julia Beatrice
Mukhopadhyay, Dwaipayan
Mengeler, Johanna Marie
Vetere, Alessandro
Sterling, Marie Sophie
Hinrichs, Heike
Becker, Stefan
Morgner, Nina
Schrader, Wolfgang
Finkemeier, Iris
Dietz, Karl-Josef
Griesinger, Christian
Ritter, Tobias
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10914617
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10914617
Other Identifiers
ISSN
1755-4330
E-ISSN
1755-4349
DOI
10.1038/s41557-023-01388-7
