2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iro...
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
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Basel: Springer Basel
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Language
English
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Basel: Springer Basel
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Contents
Recent studies have revealed that the members of an ancient family of nonheme Fe²⁺/2-oxoglutarate-dependent dioxygenases (2-OGDO) are involved in the functions associated with the aging process. 2-Oxoglutarate and O₂ are the obligatory substrates and Fe²⁺ a cofactor in the activation of 2-OGDO enzymes, which can induce the hydroxylation of distinct...
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Full title
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11114064
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11114064
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ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-015-1978-z
