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2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iro...

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iro...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11114064

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

About this item

Full title

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Publisher

Basel: Springer Basel

Journal title

Cellular and molecular life sciences : CMLS, 2015-10, Vol.72 (20), p.3897-3914

Language

English

Formats

Publication information

Publisher

Basel: Springer Basel

More information

Scope and Contents

Contents

Recent studies have revealed that the members of an ancient family of nonheme Fe²⁺/2-oxoglutarate-dependent dioxygenases (2-OGDO) are involved in the functions associated with the aging process. 2-Oxoglutarate and O₂ are the obligatory substrates and Fe²⁺ a cofactor in the activation of 2-OGDO enzymes, which can induce the hydroxylation of distinct...

Alternative Titles

Full title

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11114064

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11114064

Other Identifiers

ISSN

1420-682X

E-ISSN

1420-9071

DOI

10.1007/s00018-015-1978-z

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