The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer
The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer
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Author / Creator
Li, Kun , Yang, Bo , Du, Yingying , Ding, Yi , Shen, Shihui , Sun, Zhengwang , Liu, Yun , Wang, Yuhan , Cao, Siyuan , Ren, Wenjie , Wang, Xiangyu , Li, Mengjuan , Zhang, Yunpeng , Wu, Juan , Zheng, Wei , Yan, Wangjun and Li, Lei
Publisher
China: Springer Nature B.V
Journal title
Language
English
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Publisher
China: Springer Nature B.V
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Contents
While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients, effective treatments are still lacking. Here, we identified homeobox C10 (HOXC10) as a lynchpin in pan-KRAS-mutant lung cancer bone metastasis. Through RNA-seq approach and patient tissue studies, we demonstrated that HOXC10 expression was dramat...
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Full title
The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11349752
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11349752
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ISSN
2095-4700
E-ISSN
2095-6231
DOI
10.1038/s41413-024-00350-8
