Age‐dependent heat shock hormesis to HSF‐1 deficiency suggests a compensatory mechanism mediated by...
Age‐dependent heat shock hormesis to HSF‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans
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Publisher
England: John Wiley & Sons, Inc
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Language
English
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Publisher
England: John Wiley & Sons, Inc
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The transcription factor HSF‐1 (heat shock factor 1) acts as a master regulator of heat shock response in eukaryotic cells to maintain cellular proteostasis. The protein has a protective role in preventing cells from undergoing ageing, and neurodegeneration, and also mediates tumorigenesis. Thus, modulating HSF‐1 activity in humans has a promising...
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Full title
Age‐dependent heat shock hormesis to HSF‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11464127
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11464127
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ISSN
1474-9718,1474-9726
E-ISSN
1474-9726
DOI
10.1111/acel.14246
