AAV‐mediated gene therapy restores natural fertility and improves physical function in the Lhcgr‐def...
AAV‐mediated gene therapy restores natural fertility and improves physical function in the Lhcgr‐deficient mouse model of Leydig cell failure
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Author / Creator
Zhang, Suyuan , Yang, Bin , Shen, Xiaoting , Chen, Hong , Wang, Fulin , Tan, Zhipeng , Ou, Wangsheng , Yang, Cuifeng , Liu, Congyuan , Peng, Hao , Luo, Peng , Peng, Limei , Lei, Zhenmin , Yan, Sunxing , Wang, Tao , Ke, Qiong , Deng, Chunhua , Xiang, Andy Peng and Xia, Kai
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
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Publisher
England: John Wiley & Sons, Inc
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Scope and Contents
Contents
Leydig cell failure (LCF) caused by gene mutations leads to testosterone deficiency, infertility and reduced physical function. Adeno‐associated virus serotype 8 (AAV8)‐mediated gene therapy shows potential in treating LCF in the Lhcgr‐deficient (Lhcgr−/−) mouse model. However, the gene‐treated mice still cannot naturally sire offspring, indicating...
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Full title
AAV‐mediated gene therapy restores natural fertility and improves physical function in the Lhcgr‐deficient mouse model of Leydig cell failure
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11503244
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11503244
Other Identifiers
ISSN
0960-7722,1365-2184
E-ISSN
1365-2184
DOI
10.1111/cpr.13680
